Product Data Sheet
Derazantinib dihydrochloride
Catalog No. A28818
Derazantinib dihydrochloride is a potent inhibitor of the fibroblast growth factor receptor (FGFR) family, specifically targeting FGFR1, FGFR2, and FGFR3 with IC50 values of 4.5 nM, 1.8 nM, and 2.4 nM, respectively. Its mechanism involves competitive inhibition of ATP binding, which effectively reduces FGFR phosphorylation. This compound has demonstrated significant anti-tumor effects in various xenograft models, making it valuable for research in cancer biology and targeted therapies.
Chemical Information
| Catalog Num | A28818 |
|---|---|
| M. Wt | 541.49 |
| Formula | C29H31Cl2FN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1821329-75-2 |
| Synonyms | ARQ-087 dihydrochloride |
| SMILES | COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1.Cl.Cl |
Biological Activity
| Description | Derazantinib dihydrochloride is a potent inhibitor of the fibroblast growth factor receptor (FGFR) family, specifically targeting FGFR1, FGFR2, and FGFR3 with IC50 values of 4.5 nM, 1.8 nM, and 2.4 nM, respectively. Its mechanism involves competitive inhibition of ATP binding, which effectively reduces FGFR phosphorylation. This compound has demonstrated significant anti-tumor effects in various xenograft models, making it valuable for research in cancer biology and targeted therapies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
