Product Data Sheet
Theliatinib tartrate
Catalog No. A28819
Theliatinib tartrate is a potent, ATP-competitive inhibitor of the epidermal growth factor receptor (EGFR) with a Ki of 0.05 nM and an IC50 of 3 nM. This compound demonstrates an IC50 of 22 nM for EGFR T790M/L858R mutants and exhibits over 50-fold selectivity for EGFR compared to other kinases. Additionally, Theliatinib tartrate contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it useful for click chemistry applications in research.
Chemical Information
| Catalog Num | A28819 |
|---|---|
| M. Wt | 592.60 |
| Formula | C29H32N6O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2413487-72-4 |
| Synonyms | Xiliertinib tartrate; HMPL-309 tartrate |
| SMILES | O=C(N1C[C@]2([H])N(C)CC[C@]2([H])C1)NC3=CC4=C(NC5=CC=CC(C#C)=C5)N=CN=C4C=C3OC.OC([C@H](O)[C@@H](O)C(O)=O)=O |
Biological Activity
| Description | Theliatinib tartrate is a potent, ATP-competitive inhibitor of the epidermal growth factor receptor (EGFR) with a Ki of 0.05 nM and an IC50 of 3 nM. This compound demonstrates an IC50 of 22 nM for EGFR T790M/L858R mutants and exhibits over 50-fold selectivity for EGFR compared to other kinases. Additionally, Theliatinib tartrate contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it useful for click chemistry applications in research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
