Product Data Sheet
Afatinib impurity 11
Catalog No. A28851
Afatinib impurity 11 is an impurity associated with Afatinib, a well-known irreversible inhibitor of the epidermal growth factor receptor (EGFR) family. Afatinib exhibits potent biological activity, with IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM against wild-type EGFR, EGFRL858R, EGFRL858R/T790M, and HER2, respectively. This compound is essential for investigating the purity and synthesis of Afatinib, contributing to research focused on targeted cancer therapies.
Chemical Information
| Catalog Num | A28851 |
|---|---|
| M. Wt | 428.84 |
| Formula | C21H18ClFN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1402086-20-7 |
| Synonyms | |
| SMILES | O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)C=C |
Biological Activity
| Description | Afatinib impurity 11 is an impurity associated with Afatinib, a well-known irreversible inhibitor of the epidermal growth factor receptor (EGFR) family. Afatinib exhibits potent biological activity, with IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM against wild-type EGFR, EGFRL858R, EGFRL858R/T790M, and HER2, respectively. This compound is essential for investigating the purity and synthesis of Afatinib, contributing to research focused on targeted cancer therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
