Product Data Sheet
Gefitinib-d3
Catalog No. A28869
Gefitinib-d3 is a deuterium-labeled derivative of Gefitinib, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It exhibits robust antitumor activity by inhibiting EGF-stimulated growth in tumor cells with an IC50 of 54 nM and effectively blocking EGF-induced EGFR autophosphorylation. This stable isotope variant is particularly valuable for research applications involving drug metabolism and pharmacokinetics, as well as studying the mechanisms of autophagy associated with EGFR signaling.
Chemical Information
| Catalog Num | A28869 |
|---|---|
| M. Wt | 449.92 |
| Formula | C22H21D3ClFN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1173976-40-3 |
| Synonyms | |
| SMILES | N(C=1C2=C(C=C(OC([2H])([2H])[2H])C(OCCCN3CCOCC3)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4 |
Biological Activity
| Description | Gefitinib-d3 is a deuterium-labeled derivative of Gefitinib, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It exhibits robust antitumor activity by inhibiting EGF-stimulated growth in tumor cells with an IC50 of 54 nM and effectively blocking EGF-induced EGFR autophosphorylation. This stable isotope variant is particularly valuable for research applications involving drug metabolism and pharmacokinetics, as well as studying the mechanisms of autophagy associated with EGFR signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
