Product Data Sheet
Enozertinib
Catalog No. A28873
Enozertinib is a potent dual inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), designed for oral administration with the ability to penetrate the central nervous system. This highly selective and irreversible compound effectively targets exon 20 insertion mutations, demonstrating significant antitumor activity and inducing tumor regression in models of central nervous system and non-small cell lung cancer (NSCLC). Enozertinib is valuable for research involving solid tumors and NSCLC, offering enhanced kinome selectivity to minimize off-target effects.
Chemical Information
| Catalog Num | A28873 |
|---|---|
| M. Wt | 660.76 |
| Formula | C35H42F2N8O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2489185-38-6 |
| Synonyms | ORIC-114 |
| SMILES | C=CC(NC1=C(N2CCC(N3CCN(C4CC4)CC3)CC2)C=C(C(NC5=NC=NC(N6[C@@H](C7=CC(F)=CC(F)=C7)CCO6)=C5)=C1)OC)=O |
Biological Activity
| Description | Enozertinib is a potent dual inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), designed for oral administration with the ability to penetrate the central nervous system. This highly selective and irreversible compound effectively targets exon 20 insertion mutations, demonstrating significant antitumor activity and inducing tumor regression in models of central nervous system and non-small cell lung cancer (NSCLC). Enozertinib is valuable for research involving solid tumors and NSCLC, offering enhanced kinome selectivity to minimize off-target effects. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
