Product Data Sheet
MS9427
Catalog No. A28875
MS9427 is a selective PROTAC degrader targeting the epidermal growth factor receptor (EGFR), demonstrating Kd values of 7.1 nM and 4.3 nM for EGFR wild-type and L858R mutant forms, respectively. This compound effectively induces degradation of the mutant EGFR via both the ubiquitin/proteasome system and autophagy/lysosomal pathways, while sparing the wild-type receptor. MS9427 is a valuable tool for studying the proliferation inhibition of non-small cell lung cancer (NSCLC) cells and advancing anticancer research.
Chemical Information
| Catalog Num | A28875 |
|---|---|
| M. Wt | 993.47 |
| Formula | C48H58ClFN8O12 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2772613-37-1 |
| Synonyms | |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(NCCOCCOCCOCCOCCOCCC(N4CCN(CCCOC5=CC6=C(NC7=CC=C(F)C(Cl)=C7)N=CN=C6C=C5OC)CC4)=O)=C3)=O |
Biological Activity
| Description | MS9427 is a selective PROTAC degrader targeting the epidermal growth factor receptor (EGFR), demonstrating Kd values of 7.1 nM and 4.3 nM for EGFR wild-type and L858R mutant forms, respectively. This compound effectively induces degradation of the mutant EGFR via both the ubiquitin/proteasome system and autophagy/lysosomal pathways, while sparing the wild-type receptor. MS9427 is a valuable tool for studying the proliferation inhibition of non-small cell lung cancer (NSCLC) cells and advancing anticancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
