Product Data Sheet
Tephrosin
Catalog No. A28889
Tephrosin is a natural rotenoid that functions as an inhibitor of the epidermal growth factor receptor (EGFR) and ErbB2. It demonstrates significant antitumor activity by promoting the internalization and subsequent degradation of these receptors, thereby disrupting downstream signaling pathways involved in cellular proliferation and survival. This compound is useful in cancer research, particularly in studies focusing on targeted therapies for EGFR and ErbB2-overexpressing tumors.
Chemical Information
| Catalog Num | A28889 |
|---|---|
| M. Wt | 410.42 |
| Formula | C23H22O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 76-80-2 |
| Synonyms | Deguelinol I; Hydroxydeguelin |
| SMILES | O=C1[C@]2(O)[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC=C14 |
Biological Activity
| Description | Tephrosin is a natural rotenoid that functions as an inhibitor of the epidermal growth factor receptor (EGFR) and ErbB2. It demonstrates significant antitumor activity by promoting the internalization and subsequent degradation of these receptors, thereby disrupting downstream signaling pathways involved in cellular proliferation and survival. This compound is useful in cancer research, particularly in studies focusing on targeted therapies for EGFR and ErbB2-overexpressing tumors. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
