Product Data Sheet
PF-6274484
Catalog No. A28892
PF-6274484 is a highly selective inhibitor of the epidermal growth factor receptor (EGFR), with inhibitory constants (Kis) of 0.14 nM for the EGFR-L858R/T790M mutant and 0.18 nM for wild-type EGFR. This compound effectively inhibits autophosphorylation of EGFR-L858R/T790M in H1975 cells and wild-type EGFR in A549 cells, demonstrating IC50 values of 6.6 nM and 5.8 nM, respectively. PF-6274484 is valuable for researching targeted therapies in EGFR-driven cancers and elucidating signaling pathways linked to tumor proliferation.
Chemical Information
| Catalog Num | A28892 |
|---|---|
| M. Wt | 372.78 |
| Formula | C18H14ClFN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1035638-91-5 |
| Synonyms | |
| SMILES | C=CC(NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1OC)=O |
Biological Activity
| Description | PF-6274484 is a highly selective inhibitor of the epidermal growth factor receptor (EGFR), with inhibitory constants (Kis) of 0.14 nM for the EGFR-L858R/T790M mutant and 0.18 nM for wild-type EGFR. This compound effectively inhibits autophosphorylation of EGFR-L858R/T790M in H1975 cells and wild-type EGFR in A549 cells, demonstrating IC50 values of 6.6 nM and 5.8 nM, respectively. PF-6274484 is valuable for researching targeted therapies in EGFR-driven cancers and elucidating signaling pathways linked to tumor proliferation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
