Product Data Sheet
PDZ1i
Catalog No. A28918
PDZ1i (113B7) is a selective inhibitor of MDA-9/Syntenin, targeting its PDZ1 domain. This compound effectively inhibits radiation-induced invasion of glioblastoma (GBM) cells and enhances their radiosensitivity by disrupting key signaling pathways, including Src/EphA2, EGFRvIII/FAK, and NF-κB. PDZ1i also decreases the secretion of invasion-related proteases such as MMP-2, MMP-9, and ADAM9. Its anti-tumor efficacy has been demonstrated in nude mice models with intracranial U1242-luc and GBM xenografts, making PDZ1i a valuable tool for researching glioblastoma, as well as breast and prostate cancers.
Chemical Information
| Catalog Num | A28918 |
|---|---|
| M. Wt | 538.56 |
| Formula | C28H26N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2083618-79-3 |
| Synonyms | 113B7 |
| SMILES | O=C1N2C(NC3=C1CCC3)=NC(C(NC(C=C4C)=C(C=C4NC(CCC5=NN=C(C6=CC=CC=C6)O5)=O)C)=O)=N2 |
Biological Activity
| Description | PDZ1i (113B7) is a selective inhibitor of MDA-9/Syntenin, targeting its PDZ1 domain. This compound effectively inhibits radiation-induced invasion of glioblastoma (GBM) cells and enhances their radiosensitivity by disrupting key signaling pathways, including Src/EphA2, EGFRvIII/FAK, and NF-κB. PDZ1i also decreases the secretion of invasion-related proteases such as MMP-2, MMP-9, and ADAM9. Its anti-tumor efficacy has been demonstrated in nude mice models with intracranial U1242-luc and GBM xenografts, making PDZ1i a valuable tool for researching glioblastoma, as well as breast and prostate cancers. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
