Product Data Sheet
Ficerafusp alfa
Catalog No. A28928
Ficerafusp alfa is a bispecific antibody targeting EGFR and TGFβ with a Kd of 2.58 nM for EGFR and 61.3 nM for TGFβ1. This compound inhibits EGFR phosphorylation, thereby blocking EGF-dependent cell proliferation and facilitating antibody-dependent cellular cytotoxicity in EGFR-positive tumor cells. Additionally, Ficerafusp alfa sequesters TGFβ via its TGFβRII ECD domain, neutralizing TGFβ activity and inhibiting TGFβ-dependent processes such as epithelial-mesenchymal transition. This reagent is valuable for research on head and neck squamous cell carcinoma, advanced solid tumors, and various cancers including squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer.
Chemical Information
| Catalog Num | A28928 |
|---|---|
| M. Wt | 178.105 kDa |
| Formula | |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2764727-44-6 |
| Synonyms | BCA-101; FMAB2 |
| SMILES | [Ficerafusp alfa] |
Biological Activity
| Description | Ficerafusp alfa is a bispecific antibody targeting EGFR and TGFβ with a Kd of 2.58 nM for EGFR and 61.3 nM for TGFβ1. This compound inhibits EGFR phosphorylation, thereby blocking EGF-dependent cell proliferation and facilitating antibody-dependent cellular cytotoxicity in EGFR-positive tumor cells. Additionally, Ficerafusp alfa sequesters TGFβ via its TGFβRII ECD domain, neutralizing TGFβ activity and inhibiting TGFβ-dependent processes such as epithelial-mesenchymal transition. This reagent is valuable for research on head and neck squamous cell carcinoma, advanced solid tumors, and various cancers including squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
