Product Data Sheet
PROTAC EGFR degrader 4
Catalog No. A28945
PROTAC EGFR Degrader 4 is a highly selective PROTAC designed to target mutant epidermal growth factor receptor (EGFR) variants. It effectively induces the degradation of EGFR del19 and the EGFR L858R/T790M double mutant, with DC50 values of 0.51 nM and 126 nM, respectively. This compound demonstrates significant growth inhibition in HCC827 and H1975 cell lines, exhibiting IC50 values of 0.83 nM and 203.1 nM. The degradation of EGFR is associated with autophagy, highlighting its potential in cancer research and therapeutic applications.
Chemical Information
| Catalog Num | A28945 |
|---|---|
| M. Wt | 995.29 |
| Formula | C55H70N12O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2882845-50-1 |
| Synonyms | |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC=C7N=C(N(C7=N6)C8CCCC8)NC9=CC=CC=C9)=O)=O)O)=O |
Biological Activity
| Description | PROTAC EGFR Degrader 4 is a highly selective PROTAC designed to target mutant epidermal growth factor receptor (EGFR) variants. It effectively induces the degradation of EGFR del19 and the EGFR L858R/T790M double mutant, with DC50 values of 0.51 nM and 126 nM, respectively. This compound demonstrates significant growth inhibition in HCC827 and H1975 cell lines, exhibiting IC50 values of 0.83 nM and 203.1 nM. The degradation of EGFR is associated with autophagy, highlighting its potential in cancer research and therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
