Product Data Sheet
SK-575-NEG
Catalog No. A28981
SK-575-NEG is a PARP1 degrader designed as a methylated counterpart of SK-575, synthesized through the methylation of the amino group in piperidine-2,6-dione. It demonstrates a strong binding affinity to PARP1, with an IC50 of 2.64 nM. However, SK-575-NEG does not induce PARP1 degradation in MDA-MB-436 and Capan-1 cell lines at concentrations up to 1 μM. This compound is valuable for research focusing on the mechanistic understanding of PARP1 inhibition and degradation pathways.
Chemical Information
| Catalog Num | A28981 |
|---|---|
| M. Wt | 891.00 |
| Formula | C48H55FN8O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2523017-04-9 |
| Synonyms | |
| SMILES | O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCCCCCCC(NCCNC4=CC=CC(C(N5C6C(N(C)C(CC6)=O)=O)=O)=C4C5=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7 |
Biological Activity
| Description | SK-575-NEG is a PARP1 degrader designed as a methylated counterpart of SK-575, synthesized through the methylation of the amino group in piperidine-2,6-dione. It demonstrates a strong binding affinity to PARP1, with an IC50 of 2.64 nM. However, SK-575-NEG does not induce PARP1 degradation in MDA-MB-436 and Capan-1 cell lines at concentrations up to 1 μM. This compound is valuable for research focusing on the mechanistic understanding of PARP1 inhibition and degradation pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
