Product Data Sheet
PARP1/2-IN-3
Catalog No. A28985
PARP1/2-IN-3 is a potent inhibitor of PARP1 and PARP2, exhibiting IC50 values of 0.2235 nM and <0.001 nM, respectively. This compound effectively inhibits the proliferation of Capan-1 wildtype and AZD2281 or BMN673-resistant cells, with IC50 values ranging from 1.82 to 9.98 nM. Additionally, PARP1/2-IN-3 demonstrates significant antitumor efficacy in murine models, making it a valuable tool for cancer research and therapeutic development targeting PARP pathways.
Chemical Information
| Catalog Num | A28985 |
|---|---|
| M. Wt | 484.48 |
| Formula | C26H21FN6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3032451-58-1 |
| Synonyms | |
| SMILES | CC1=CC=C(O1)C2=NN=C3CN(CCN32)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O |
Biological Activity
| Description | PARP1/2-IN-3 is a potent inhibitor of PARP1 and PARP2, exhibiting IC50 values of 0.2235 nM and <0.001 nM, respectively. This compound effectively inhibits the proliferation of Capan-1 wildtype and AZD2281 or BMN673-resistant cells, with IC50 values ranging from 1.82 to 9.98 nM. Additionally, PARP1/2-IN-3 demonstrates significant antitumor efficacy in murine models, making it a valuable tool for cancer research and therapeutic development targeting PARP pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
