Product Data Sheet
MHY219
Catalog No. A29074
MHY219 is a potent histone deacetylase (HDAC) inhibitor with an IC50 of 0.276 μM, effectively inhibiting total HDAC enzyme activity. This compound promotes histone H3 and H4 hyperacetylation, leading to cell cycle arrest, apoptosis, and reduced proliferation in cancer cells. Additionally, MHY219 enhances cleavage of PARP, Bax, and cytochrome c levels, while upregulating androgen receptor expression and downregulating Bcl-2 expression. It serves as a valuable research tool for studying prostate cancer mechanisms and potential therapeutic strategies.
Chemical Information
| Catalog Num | A29074 |
|---|---|
| M. Wt | 355.43 |
| Formula | C20H25N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1326750-61-1 |
| Synonyms | |
| SMILES | O=C(NO)CCCCCCC(NC1=CC=C(NC2=CC=CC=C2)C=C1)=O |
Biological Activity
| Description | MHY219 is a potent histone deacetylase (HDAC) inhibitor with an IC50 of 0.276 μM, effectively inhibiting total HDAC enzyme activity. This compound promotes histone H3 and H4 hyperacetylation, leading to cell cycle arrest, apoptosis, and reduced proliferation in cancer cells. Additionally, MHY219 enhances cleavage of PARP, Bax, and cytochrome c levels, while upregulating androgen receptor expression and downregulating Bcl-2 expression. It serves as a valuable research tool for studying prostate cancer mechanisms and potential therapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
