Product Data Sheet
P300-IN-6
Catalog No. A29152
P300-IN-6 is an orally bioavailable inhibitor targeting the histone acetyltransferase p300 HAT domain, exhibiting a human IC50 of 7 nM. This compound effectively suppresses c-Myc expression and reduces acetylation levels of histones H3K18 and H3K27, leading to inhibition of cancer cell proliferation. P300-IN-6 demonstrates significant antitumor activity in xenograft mouse models, making it a valuable tool for investigating therapeutic strategies in multiple myeloma research.
Chemical Information
| Catalog Num | A29152 |
|---|---|
| M. Wt | 454.52 |
| Formula | C26H26N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3034595-62-2 |
| Synonyms | |
| SMILES | CN1C2=CC=C(NC([C@@H](C3=CC=CC=C3)NC[C@@H](C)C4=CC=C(C#N)C=C4)=O)N=C2N(C)C1=O |
Biological Activity
| Description | P300-IN-6 is an orally bioavailable inhibitor targeting the histone acetyltransferase p300 HAT domain, exhibiting a human IC50 of 7 nM. This compound effectively suppresses c-Myc expression and reduces acetylation levels of histones H3K18 and H3K27, leading to inhibition of cancer cell proliferation. P300-IN-6 demonstrates significant antitumor activity in xenograft mouse models, making it a valuable tool for investigating therapeutic strategies in multiple myeloma research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
