Product Data Sheet
QC-182
Catalog No. A29200
QC-182 is a potent PROTAC degrader targeting p300/CBP, facilitating the degradation of these proteins. It effectively reduces p300 protein levels in SK-HEP-1 cells, with a DC50 of 93 nM. Additionally, QC-182 demonstrates significant growth inhibition in SK-HEP-1 and JHH7 cell lines, with IC50 values of 0.733 μM and 0.477 μM, respectively. This reagent is valuable for research focused on hepatocellular carcinoma (HCC).
Chemical Information
| Catalog Num | A29200 |
|---|---|
| M. Wt | 816.85 |
| Formula | C44H42F2N8O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3032646-96-8 |
| Synonyms | |
| SMILES | O=C1N(C2C(NC(CC2)=O)=O)C(C(C1=C3)=CC=C3N(C4)CC4N5CCC(N6C7=CC=C(C8=C(C)ON=C8C)C=C7N=C6[C@H]9N(C%10=CC(F)=C(F)C=C%10)C(CCC9)=O)CC5)=O |
Biological Activity
| Description | QC-182 is a potent PROTAC degrader targeting p300/CBP, facilitating the degradation of these proteins. It effectively reduces p300 protein levels in SK-HEP-1 cells, with a DC50 of 93 nM. Additionally, QC-182 demonstrates significant growth inhibition in SK-HEP-1 and JHH7 cell lines, with IC50 values of 0.733 μM and 0.477 μM, respectively. This reagent is valuable for research focused on hepatocellular carcinoma (HCC). |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
