Product Data Sheet
LSD1-IN-19
Catalog No. A29260
LSD1-IN-19 is a potent and selective inhibitor of the lysine-specific demethylase 1 (LSD1), exhibiting a Ki value of 0.108 μM and a KD of 0.068 μM. This compound demonstrates significant antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 values of 0.17 μM and 0.40 μM, respectively, over a 72-hour treatment period. LSD1-IN-19 is valuable for investigating the role of LSD1 in cancer biology and may serve as a potential therapeutic candidate in the treatment of cancers driven by epigenetic regulation.
Chemical Information
| Catalog Num | A29260 |
|---|---|
| M. Wt | 554.73 |
| Formula | C33H42N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2983011-81-8 |
| Synonyms | |
| SMILES | COC1=CC2=C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)NCCCN(C)C)C=C1OCC5=CC=CC=C5 |
Biological Activity
| Description | LSD1-IN-19 is a potent and selective inhibitor of the lysine-specific demethylase 1 (LSD1), exhibiting a Ki value of 0.108 μM and a KD of 0.068 μM. This compound demonstrates significant antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 values of 0.17 μM and 0.40 μM, respectively, over a 72-hour treatment period. LSD1-IN-19 is valuable for investigating the role of LSD1 in cancer biology and may serve as a potential therapeutic candidate in the treatment of cancers driven by epigenetic regulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
