Product Data Sheet
Pulrodemstat
Catalog No. A29271
Pulrodemstat is a potent and reversible inhibitor of lysine specific demethylase-1 (LSD1), exhibiting an IC50 of 0.25 nM, while demonstrating minimal inhibition of LSD2, MAO-A, and MAO-B. This compound effectively promotes differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells, showcasing its significant anticancer properties. Due to its selective action, Pulrodemstat serves as a valuable tool for exploring the therapeutic potential of LSD1 inhibition in cancer research.
Chemical Information
| Catalog Num | A29271 |
|---|---|
| M. Wt | 451.47 |
| Formula | C24H23F2N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1821307-10-1 |
| Synonyms | CC-90011; LSD1-IN-7 |
| SMILES | N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F |
Biological Activity
| Description | Pulrodemstat is a potent and reversible inhibitor of lysine specific demethylase-1 (LSD1), exhibiting an IC50 of 0.25 nM, while demonstrating minimal inhibition of LSD2, MAO-A, and MAO-B. This compound effectively promotes differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells, showcasing its significant anticancer properties. Due to its selective action, Pulrodemstat serves as a valuable tool for exploring the therapeutic potential of LSD1 inhibition in cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
