Product Data Sheet
CBB1007 trihydrochloride
Catalog No. A29273
CBB1007 trihydrochloride is a reversible and selective inhibitor of lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 5.27 µM for human LSD1. It effectively inhibits LSD1's demethylase activity on H3K4Me2 and H3K4Me, demonstrating notable selectivity for LSD1 over LSD2 and JARID1A. This compound has significant implications in cancer research, particularly in non-pluripotent models, as it promotes the expression of differentiation-related genes in pluripotent cells and is being explored in the context of teratocarcinoma, embryonic carcinoma, and seminoma.
Chemical Information
| Catalog Num | A29273 |
|---|---|
| M. Wt | 643.99 |
| Formula | C27H37Cl3N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2070015-03-9 |
| Synonyms | |
| SMILES | NC(N1CCN(CC1)CC2=CC(C(OC)=O)=CC(C(N3CCN(CC3)C(C4=CC=C(C=C4)C(N)=N)=O)=O)=C2)=N.[H]Cl.[H]Cl.[H]Cl |
Biological Activity
| Description | CBB1007 trihydrochloride is a reversible and selective inhibitor of lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 5.27 µM for human LSD1. It effectively inhibits LSD1's demethylase activity on H3K4Me2 and H3K4Me, demonstrating notable selectivity for LSD1 over LSD2 and JARID1A. This compound has significant implications in cancer research, particularly in non-pluripotent models, as it promotes the expression of differentiation-related genes in pluripotent cells and is being explored in the context of teratocarcinoma, embryonic carcinoma, and seminoma. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
