Product Data Sheet
NCDM-32B
Catalog No. A29278
NCDM-32B is a selective inhibitor of KDM4, demonstrating IC50 values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. This compound significantly enhances global levels of H3K9me3/me2 in basal breast cancer cells, contributing to impaired cell viability in KDM4C-amplified breast cancer cell lines such as HCC1954 and Colo824. NCDM-32B serves as a valuable tool for investigating the role of KDM4 in breast cancer research and therapeutic development.
Chemical Information
| Catalog Num | A29278 |
|---|---|
| M. Wt | 302.41 |
| Formula | C15H30N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1239468-48-4 |
| Synonyms | |
| SMILES | O=C(CCN(O)C(CCCCCCCCN(C)C)=O)OC |
Biological Activity
| Description | NCDM-32B is a selective inhibitor of KDM4, demonstrating IC50 values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. This compound significantly enhances global levels of H3K9me3/me2 in basal breast cancer cells, contributing to impaired cell viability in KDM4C-amplified breast cancer cell lines such as HCC1954 and Colo824. NCDM-32B serves as a valuable tool for investigating the role of KDM4 in breast cancer research and therapeutic development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
