Product Data Sheet
Pulrodemstat Methylbenzenesulfonate
Catalog No. A29281
Pulrodemstat Methylbenzenesulfonate is a selective, reversible inhibitor of lysine-specific demethylase-1 (LSD1), exhibiting an IC50 of 0.25 nM. This compound demonstrates minimal inhibition of LSD2, monoamine oxidase A, and monoamine oxidase B. Pulrodemstat Methylbenzenesulfonate effectively induces differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells, showcasing significant anticancer activity. Its targeted action positions it as a valuable reagent in cancer research and therapeutic studies.
Chemical Information
| Catalog Num | A29281 |
|---|---|
| M. Wt | 623.67 |
| Formula | C31H31F2N5O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2097523-57-2 |
| Synonyms | CC-90011 Methylbenzenesulfonate; LSD1-IN-7 Methylbenzenesulfonate |
| SMILES | N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.O=S(C5=CC=C(C)C=C5)(O)=O |
Biological Activity
| Description | Pulrodemstat Methylbenzenesulfonate is a selective, reversible inhibitor of lysine-specific demethylase-1 (LSD1), exhibiting an IC50 of 0.25 nM. This compound demonstrates minimal inhibition of LSD2, monoamine oxidase A, and monoamine oxidase B. Pulrodemstat Methylbenzenesulfonate effectively induces differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells, showcasing significant anticancer activity. Its targeted action positions it as a valuable reagent in cancer research and therapeutic studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
