Product Data Sheet
Naratriptan-d3
Catalog No. A29350
Naratriptan-d3 is a deuterium-labeled variant of Naratriptan, functioning primarily as an agonist of the 5-HT1B/1D receptors. This compound is known for its peripheral activity and favorable oral bioavailability, effectively inducing vasoconstriction of cranial arteries by activating the specified receptors with an EC50 of 0.11 μM in canine basilar artery models. Naratriptan-d3 also plays a role in inhibiting migraine-associated trigeminal nerve activity and reducing sterile inflammation, making it a valuable tool for investigating acute migraine mechanisms and associated cranial vascular and neuroinflammatory pathways.
Chemical Information
| Catalog Num | A29350 |
|---|---|
| M. Wt | 338.48 |
| Formula | C17H22D3N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1190043-69-6 |
| Synonyms | GR-85548A-d3-1 |
| SMILES | CNS(CCC1=CC=C2NC=C(C3CCN(CC3)C([2H])([2H])[2H])C2=C1)(=O)=O |
Biological Activity
| Description | Naratriptan-d3 is a deuterium-labeled variant of Naratriptan, functioning primarily as an agonist of the 5-HT1B/1D receptors. This compound is known for its peripheral activity and favorable oral bioavailability, effectively inducing vasoconstriction of cranial arteries by activating the specified receptors with an EC50 of 0.11 μM in canine basilar artery models. Naratriptan-d3 also plays a role in inhibiting migraine-associated trigeminal nerve activity and reducing sterile inflammation, making it a valuable tool for investigating acute migraine mechanisms and associated cranial vascular and neuroinflammatory pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
