Product Data Sheet
WAY-100289
Catalog No. A29376
WAY-100289 is a selective antagonist of the 5-HT3 receptor, demonstrating high affinity with a pA2 value of 8.9 in isolated rat vagus nerve studies. This compound effectively inhibits the Bezold-Jarisch reflex in both anesthetized and awake rat models, highlighting its potential applications in neuropharmacological research and studies of gastrointestinal function. Its oral bioavailability makes it a valuable tool for investigating the therapeutic roles of 5-HT3 receptor modulation in various physiological and pathological states.
Chemical Information
| Catalog Num | A29376 |
|---|---|
| M. Wt | 357.45 |
| Formula | C20H27N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 136013-69-9 |
| Synonyms | |
| SMILES | O=C(NC(N[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)=O)C3=CC=CC=C3OCC4CC4 |
Biological Activity
| Description | WAY-100289 is a selective antagonist of the 5-HT3 receptor, demonstrating high affinity with a pA2 value of 8.9 in isolated rat vagus nerve studies. This compound effectively inhibits the Bezold-Jarisch reflex in both anesthetized and awake rat models, highlighting its potential applications in neuropharmacological research and studies of gastrointestinal function. Its oral bioavailability makes it a valuable tool for investigating the therapeutic roles of 5-HT3 receptor modulation in various physiological and pathological states. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
