Product Data Sheet
SB-649915
Catalog No. A29395
SB-649915 is a potent antagonist of the 5-HT1A and 5-HT1B autoreceptors, demonstrating pKi values of 8.6 and 8.0, respectively. This compound also acts as a serotonin reuptake inhibitor in native tissue systems, making it valuable for investigating the mechanisms underlying antidepressant therapies. Its ability to modulate serotonergic signaling supports its role in research related to mood disorders and other neuropsychiatric conditions.
Chemical Information
| Catalog Num | A29395 |
|---|---|
| M. Wt | 431.53 |
| Formula | C26H29N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 420785-70-2 |
| Synonyms | |
| SMILES | O=C1COC2=CC=C(CC3CCN(CCOC4=C5C=CC(C)=NC5=CC=C4)CC3)C=C2N1 |
Biological Activity
| Description | SB-649915 is a potent antagonist of the 5-HT1A and 5-HT1B autoreceptors, demonstrating pKi values of 8.6 and 8.0, respectively. This compound also acts as a serotonin reuptake inhibitor in native tissue systems, making it valuable for investigating the mechanisms underlying antidepressant therapies. Its ability to modulate serotonergic signaling supports its role in research related to mood disorders and other neuropsychiatric conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
