Product Data Sheet
SB-236057
Catalog No. A29402
SB-236057 is an inverse agonist of the 5-HT1B receptor, known for its significant impact on skeletal development in animal models. This compound influences gene expression during embryonic development by disrupting the Notch signaling pathway and interacting with r-esp1. In preclinical studies, SB-236057 has been shown to cause somatic patterning and tail extension defects in rat embryos, making it a valuable tool for investigating developmental biology and teratogenicity.
Chemical Information
| Catalog Num | A29402 |
|---|---|
| M. Wt | 534.65 |
| Formula | C33H34N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 180083-49-2 |
| Synonyms | |
| SMILES | O=C(N1C2=CC3=C(C=C2CC1)OCC34CCN(CC4)CC)C5=CC=C(C6=C(C)C=C(C7=NN=C(C)O7)C=C6)C=C5 |
Biological Activity
| Description | SB-236057 is an inverse agonist of the 5-HT1B receptor, known for its significant impact on skeletal development in animal models. This compound influences gene expression during embryonic development by disrupting the Notch signaling pathway and interacting with r-esp1. In preclinical studies, SB-236057 has been shown to cause somatic patterning and tail extension defects in rat embryos, making it a valuable tool for investigating developmental biology and teratogenicity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
