Product Data Sheet
SB-203186
Catalog No. A29428
SB-203186 is a highly selective antagonist of the 5-HT4 receptor. It demonstrates a potent competitive antagonistic effect, as evidenced by its pKB value of 8.3 in the isolated right atrium model of piglets. The compound effectively shifts the serotonin-induced tachycardia curve to the right in a dose-dependent manner without inhibiting the maximum response. While SB-203186 shows significant antagonistic activity in pig and human atria, it does not exhibit substantial effects in rat atria, making it valuable for investigating conditions such as arrhythmias and abnormal myocardial contraction.
Chemical Information
| Catalog Num | A29428 |
|---|---|
| M. Wt | 272.34 |
| Formula | C16H20N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 135938-17-9 |
| Synonyms | |
| SMILES | O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3 |
Biological Activity
| Description | SB-203186 is a highly selective antagonist of the 5-HT4 receptor. It demonstrates a potent competitive antagonistic effect, as evidenced by its pKB value of 8.3 in the isolated right atrium model of piglets. The compound effectively shifts the serotonin-induced tachycardia curve to the right in a dose-dependent manner without inhibiting the maximum response. While SB-203186 shows significant antagonistic activity in pig and human atria, it does not exhibit substantial effects in rat atria, making it valuable for investigating conditions such as arrhythmias and abnormal myocardial contraction. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
