Product Data Sheet
LY53857
Catalog No. A29462
LY53857 is a potent antagonist of the 5-HT2 receptor, effectively inhibiting vasoconstriction mediated by serotonin. In preclinical studies, LY53857 demonstrated the ability to block the depressor response to serotonin without significantly affecting mean arterial blood pressure in spontaneously hypertensive rats. Furthermore, LY53857 enhances neurotransmitter release in rat vas deferens and guinea pig ileal nerves, indicating its potential utility in elucidating serotonergic signaling pathways and exploring therapeutic applications in related cardiovascular and neural disorders.
Chemical Information
| Catalog Num | A29462 |
|---|---|
| M. Wt | 500.58 |
| Formula | C27H36N2O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 60634-51-7 |
| Synonyms | |
| SMILES | OC(/C=C\C(O)=O)=O.CC(N1C2=C3C([C@]4([H])[C@@](N(C[C@@H](C4)C(OC(C)C(O)C)=O)C)([H])CC3=C1)=CC=C2)C |
Biological Activity
| Description | LY53857 is a potent antagonist of the 5-HT2 receptor, effectively inhibiting vasoconstriction mediated by serotonin. In preclinical studies, LY53857 demonstrated the ability to block the depressor response to serotonin without significantly affecting mean arterial blood pressure in spontaneously hypertensive rats. Furthermore, LY53857 enhances neurotransmitter release in rat vas deferens and guinea pig ileal nerves, indicating its potential utility in elucidating serotonergic signaling pathways and exploring therapeutic applications in related cardiovascular and neural disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
