Product Data Sheet
Lurosetron
Catalog No. A29476
Lurosetron is a potent 5-HT3 receptor antagonist, specifically developed as a 6-fluoro analogue of Alosetron. This compound demonstrates significant biological activity through the inhibition of recombinant cytochrome P450 isoforms, including rbtCYP1A2 with an IC50 of 0.1 μM, as well as rbtCYP2C9 and rbtCYP3A4, exhibiting IC50 values ranging from 3.5 μM to 16 μM. Lurosetron is primarily utilized in research focused on gastrointestinal disorders and the modulation of serotonin pathways.
Chemical Information
| Catalog Num | A29476 |
|---|---|
| M. Wt | 312.34 |
| Formula | C17H17FN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 128486-54-4 |
| Synonyms | GR-87442 |
| SMILES | O=C1C2=C(CCN1CC3=C(NC=N3)C)N(C)C4=C2C=CC=C4F |
Biological Activity
| Description | Lurosetron is a potent 5-HT3 receptor antagonist, specifically developed as a 6-fluoro analogue of Alosetron. This compound demonstrates significant biological activity through the inhibition of recombinant cytochrome P450 isoforms, including rbtCYP1A2 with an IC50 of 0.1 μM, as well as rbtCYP2C9 and rbtCYP3A4, exhibiting IC50 values ranging from 3.5 μM to 16 μM. Lurosetron is primarily utilized in research focused on gastrointestinal disorders and the modulation of serotonin pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
