Product Data Sheet
PZ-1922 free base
Catalog No. A29500
PZ-1922 free base is a centrally-active antagonist of the 5-HT6 receptor and the 5-HT3 receptor, exhibiting binding affinities of Ki values of 17 nM and 0.45 nM, respectively. This compound also reversibly inhibits monoamine oxidase B, with a pIC50 of 8.93. PZ-1922 free base has demonstrated efficacy in reversing memory deficits induced by Scopolamine in novel object recognition tests in rats, as well as preventing beta-amyloid-induced cognitive decline in T-maze assessments. These properties make it a valuable tool for investigating neuropharmacology and disorders related to memory impairment.
Chemical Information
| Catalog Num | A29500 |
|---|---|
| M. Wt | 376.88 |
| Formula | C22H21ClN4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1648745-65-6 |
| Synonyms | |
| SMILES | ClC1=CC=CC(CN2C=CC3=C2C4=C(C=CC=C4)N=C3N5CCNCC5)=C1 |
Biological Activity
| Description | PZ-1922 free base is a centrally-active antagonist of the 5-HT6 receptor and the 5-HT3 receptor, exhibiting binding affinities of Ki values of 17 nM and 0.45 nM, respectively. This compound also reversibly inhibits monoamine oxidase B, with a pIC50 of 8.93. PZ-1922 free base has demonstrated efficacy in reversing memory deficits induced by Scopolamine in novel object recognition tests in rats, as well as preventing beta-amyloid-induced cognitive decline in T-maze assessments. These properties make it a valuable tool for investigating neuropharmacology and disorders related to memory impairment. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
