Product Data Sheet
5-HT6 inverse agonist 1
Catalog No. A29517
5-HT6 Inverse Agonist 1 is a selective antagonist of the 5-HT6 receptor, exhibiting a Ki of 23 nM and a Kb of 6.62 nM. This compound effectively inhibits the 5-HT6R-mediated signaling pathways, including Cdk5 and mTOR. Additionally, 5-HT6 Inverse Agonist 1 has demonstrated efficacy in reducing tactile hypersensitivity in a rat model of spinal nerve ligation, making it a valuable tool for research into pain management and neurobiology.
Chemical Information
| Catalog Num | A29517 |
|---|---|
| M. Wt | 498.40 |
| Formula | C22H22Cl2FN3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2727088-38-0 |
| Synonyms | |
| SMILES | O=C(NC1CCNCC1)C2=C(N(C=C2)S(=O)(C3=CC=CC(Cl)=C3)=O)C4=CC=C(C=C4)F.Cl |
Biological Activity
| Description | 5-HT6 Inverse Agonist 1 is a selective antagonist of the 5-HT6 receptor, exhibiting a Ki of 23 nM and a Kb of 6.62 nM. This compound effectively inhibits the 5-HT6R-mediated signaling pathways, including Cdk5 and mTOR. Additionally, 5-HT6 Inverse Agonist 1 has demonstrated efficacy in reducing tactile hypersensitivity in a rat model of spinal nerve ligation, making it a valuable tool for research into pain management and neurobiology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
