Product Data Sheet
m-Chlorophenylbiguanide
Catalog No. A29545
m-Chlorophenylbiguanide (mCPBG) is a high-affinity agonist of the 5-HT3 receptor, known to inhibit long-term potentiation (LTP) in the mossy fiber-CA3 circuit. It effectively reduces the magnitude of LTP at concentrations ranging from 0.3 to 1 µM, highlighting its significant role in the modulation of synaptic plasticity. Furthermore, the reversible nature of mCPBG's effect on LTP in the presence of the GABAA receptor antagonist bicuculline suggests its involvement in GABAergic neurotransmission pathways.
Chemical Information
| Catalog Num | A29545 |
|---|---|
| M. Wt | 211.65 |
| Formula | C8H10ClN5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 48144-44-1 |
| Synonyms | mCPBG |
| SMILES | N=C(NC1=CC=CC(Cl)=C1)NC(N)=N |
Biological Activity
| Description | m-Chlorophenylbiguanide (mCPBG) is a high-affinity agonist of the 5-HT3 receptor, known to inhibit long-term potentiation (LTP) in the mossy fiber-CA3 circuit. It effectively reduces the magnitude of LTP at concentrations ranging from 0.3 to 1 µM, highlighting its significant role in the modulation of synaptic plasticity. Furthermore, the reversible nature of mCPBG's effect on LTP in the presence of the GABAA receptor antagonist bicuculline suggests its involvement in GABAergic neurotransmission pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
