Product Data Sheet
Clozapine-d3
Catalog No. A29562
Clozapine-d3 is a deuterium-labeled derivative of Clozapine, primarily targeting neuroreceptors involved in psychiatric disorders. This compound exhibits high affinity as a dopamine D2 receptor antagonist with a Ki of 75 nM, while also inhibiting the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Additionally, Clozapine-d3 acts as a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM), making it valuable for investigations into schizophrenia and related neurochemical pathways.
Chemical Information
| Catalog Num | A29562 |
|---|---|
| M. Wt | 329.84 |
| Formula | C18H16D3ClN4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1215691-72-7 |
| Synonyms | HF 1854-d3 |
| SMILES | [2H]C(N1CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1)([2H])[2H] |
Biological Activity
| Description | Clozapine-d3 is a deuterium-labeled derivative of Clozapine, primarily targeting neuroreceptors involved in psychiatric disorders. This compound exhibits high affinity as a dopamine D2 receptor antagonist with a Ki of 75 nM, while also inhibiting the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Additionally, Clozapine-d3 acts as a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM), making it valuable for investigations into schizophrenia and related neurochemical pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
