Product Data Sheet
YM114
Catalog No. A29616
YM114 is a highly selective antagonist of the 5-HT3 receptor, demonstrating notable potency in inhibiting receptor activity. It has been shown to disrupt the Bezold-Jarisch reflex induced by 2-methyl-5-HT without affecting bradycardia resulting from Veratridine or electrical stimulation in anesthetized rats. This compound offers valuable insights into cardiovascular and neuropharmacological research applications, particularly in understanding the role of 5-HT3 receptors in vagal afferent nerve signaling.
Chemical Information
| Catalog Num | A29616 |
|---|---|
| M. Wt | 303.79 |
| Formula | C16H18ClN3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 153608-99-2 |
| Synonyms | KAE-393 |
| SMILES | O=C([C@H]1CC2=C(N=CN2)CC1)N3C4=CC=CC=C4CC3.Cl |
Biological Activity
| Description | YM114 is a highly selective antagonist of the 5-HT3 receptor, demonstrating notable potency in inhibiting receptor activity. It has been shown to disrupt the Bezold-Jarisch reflex induced by 2-methyl-5-HT without affecting bradycardia resulting from Veratridine or electrical stimulation in anesthetized rats. This compound offers valuable insights into cardiovascular and neuropharmacological research applications, particularly in understanding the role of 5-HT3 receptors in vagal afferent nerve signaling. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
