Product Data Sheet
Avitriptan
Catalog No. A29618
Avitriptan is a selective agonist of the 5-HT1B and 5-HT1D receptors, exhibiting pKis of 7.44 for 5-HT1B in rats, 7.68 for 5-HT1B in humans, and 8.36 for 5-HT1D in humans. This compound induces vasoconstriction in isolated coronary arteries, suggesting its relevance in cardiovascular research. Avitriptan is primarily utilized in the treatment of migraines, providing insights into serotonergic pathways and their role in headache disorders.
Chemical Information
| Catalog Num | A29618 |
|---|---|
| M. Wt | 458.58 |
| Formula | C22H30N6O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 151140-96-4 |
| Synonyms | BMS 180048 |
| SMILES | O=S(NC)(CC1=CC2=C(NC=C2CCCN3CCN(CC3)C4=C(OC)C=NC=N4)C=C1)=O |
Biological Activity
| Description | Avitriptan is a selective agonist of the 5-HT1B and 5-HT1D receptors, exhibiting pKis of 7.44 for 5-HT1B in rats, 7.68 for 5-HT1B in humans, and 8.36 for 5-HT1D in humans. This compound induces vasoconstriction in isolated coronary arteries, suggesting its relevance in cardiovascular research. Avitriptan is primarily utilized in the treatment of migraines, providing insights into serotonergic pathways and their role in headache disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
