Product Data Sheet
BMY 28674
Catalog No. A29623
BMY 28674 (6-Hydroxybuspirone) is a significant drug metabolite of the anxiolytic agent buspirone, primarily metabolized by CYP3A4. This compound exhibits selective binding to the serotonin receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe, with effective concentrations (EC50s) of 4 μM and 1 μM, respectively. Additionally, BMY 28674 acts as an antagonist at dopamine D2, D3, and D4 receptors, demonstrating inhibitory constants (IC50s) of 3.1 μM, 4.9 μM, and 0.85 μM, respectively. Moreover, it inhibits the activity of organic cation transporters OCT1, OCT2, and OCT3 in human proximal tubule cells in a concentration-dependent manner, making it relevant for pharmacological studies involving these receptors and transporters.
Chemical Information
| Catalog Num | A29623 |
|---|---|
| M. Wt | 401.50 |
| Formula | C21H31N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 125481-61-0 |
| Synonyms | 6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528215 |
| SMILES | O=C(N(CCCCN1CCN(C2=NC=CC=N2)CC1)C(C3)=O)C(O)C43CCCC4 |
Biological Activity
| Description | BMY 28674 (6-Hydroxybuspirone) is a significant drug metabolite of the anxiolytic agent buspirone, primarily metabolized by CYP3A4. This compound exhibits selective binding to the serotonin receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe, with effective concentrations (EC50s) of 4 μM and 1 μM, respectively. Additionally, BMY 28674 acts as an antagonist at dopamine D2, D3, and D4 receptors, demonstrating inhibitory constants (IC50s) of 3.1 μM, 4.9 μM, and 0.85 μM, respectively. Moreover, it inhibits the activity of organic cation transporters OCT1, OCT2, and OCT3 in human proximal tubule cells in a concentration-dependent manner, making it relevant for pharmacological studies involving these receptors and transporters. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
