Product Data Sheet
PZ-1129
Catalog No. A29656
PZ-1129 is a selective ligand for the 5-HT7 receptor, exhibiting a Ki of 7 nM, with moderate affinity for 5-HT1A and D2 receptors (Ki values of 159 nM and 24 nM, respectively). This compound effectively inhibits constitutive cAMP production via the Gs signaling pathway, with an EC50 of 13.7 nM. PZ-1129 is suitable for research into emotional disorders, including depression and bipolar disorder, providing a valuable tool for understanding the underlying mechanisms of these conditions.
Chemical Information
| Catalog Num | A29656 |
|---|---|
| M. Wt | 454.56 |
| Formula | C25H27FN2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1919029-61-0 |
| Synonyms | |
| SMILES | O=S(NC1CCN(CC1)CCOC2=C(C3=CC=CC=C3)C=CC=C2)(C4=CC=C(C=C4)F)=O |
Biological Activity
| Description | PZ-1129 is a selective ligand for the 5-HT7 receptor, exhibiting a Ki of 7 nM, with moderate affinity for 5-HT1A and D2 receptors (Ki values of 159 nM and 24 nM, respectively). This compound effectively inhibits constitutive cAMP production via the Gs signaling pathway, with an EC50 of 13.7 nM. PZ-1129 is suitable for research into emotional disorders, including depression and bipolar disorder, providing a valuable tool for understanding the underlying mechanisms of these conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
