Product Data Sheet
SB-272183
Catalog No. A29664
SB-272183 is a selective antagonist of the 5-HT1A, 5-HT1B, and 5-HT1D receptors, demonstrating high binding affinity with pKi values of 8.0, 8.1, and 8.7, respectively, in both human recombinant and native tissues. Its primary mechanism targets serotonin receptors, making it a valuable tool for studying the role of serotonin signaling in various biological processes. SB-272183 is particularly relevant in antidepressant research, aiding in the exploration of potential therapeutic pathways for mood disorders.
Chemical Information
| Catalog Num | A29664 |
|---|---|
| M. Wt | 498.02 |
| Formula | C29H28ClN5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 216058-27-4 |
| Synonyms | |
| SMILES | O=C(N1C2=CC(N3CCN(CC3)C)=C(C=C2CC1)Cl)NC4=C5C=CC=CC5=C(C6=CC=NC=C6)C=C4 |
Biological Activity
| Description | SB-272183 is a selective antagonist of the 5-HT1A, 5-HT1B, and 5-HT1D receptors, demonstrating high binding affinity with pKi values of 8.0, 8.1, and 8.7, respectively, in both human recombinant and native tissues. Its primary mechanism targets serotonin receptors, making it a valuable tool for studying the role of serotonin signaling in various biological processes. SB-272183 is particularly relevant in antidepressant research, aiding in the exploration of potential therapeutic pathways for mood disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
