Product Data Sheet
LY320954
Catalog No. A29688
LY320954 is a selective antagonist of the 5-HT2A receptor, exhibiting a Ki value of 96 nM. This compound effectively diminishes Ca2+ influx in cellular assays, demonstrating an EC50 of 35.5 nM. Additionally, LY320954 has shown significant efficacy in vivo by reducing 5-HT-induced paw swelling in rat models, with an ED50 of 4.8 mg/kg. This makes it a valuable tool for research into psychiatric disorders and the role of serotonergic signaling.
Chemical Information
| Catalog Num | A29688 |
|---|---|
| M. Wt | 382.46 |
| Formula | C21H26N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 182633-59-6 |
| Synonyms | |
| SMILES | CCCC1=C(O)C(C(CC)=O)=CC=C1COC2=CC=C(/C=N/NC(N)=N)C=C2 |
Biological Activity
| Description | LY320954 is a selective antagonist of the 5-HT2A receptor, exhibiting a Ki value of 96 nM. This compound effectively diminishes Ca2+ influx in cellular assays, demonstrating an EC50 of 35.5 nM. Additionally, LY320954 has shown significant efficacy in vivo by reducing 5-HT-induced paw swelling in rat models, with an ED50 of 4.8 mg/kg. This makes it a valuable tool for research into psychiatric disorders and the role of serotonergic signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
