Product Data Sheet
L-772405
Catalog No. A29693
L-772405 is a selective agonist for the 5-HT1D receptor, demonstrating Ki values of 318 nM and 29 nM against guinea pig 5-HT1B and 5-HT1D receptors, respectively, while exhibiting a Ki value greater than 1000 nM for the rat 5-HT transporter. This compound effectively reduces potassium-induced serotonin (5-HT) release, with an IC50 of 240 nM. L-772405 is valuable in exploring serotonergic signaling and could serve as a useful tool in studies of mood disorders and other neurological research applications.
Chemical Information
| Catalog Num | A29693 |
|---|---|
| M. Wt | 462.56 |
| Formula | C26H31FN6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 177947-03-4 |
| Synonyms | |
| SMILES | OC[C@@H](C1=CC=C(C=C1)F)NC(CC2)CCN2CCCC3=CNC4=CC=C(N5C=NN=C5)C=C34 |
Biological Activity
| Description | L-772405 is a selective agonist for the 5-HT1D receptor, demonstrating Ki values of 318 nM and 29 nM against guinea pig 5-HT1B and 5-HT1D receptors, respectively, while exhibiting a Ki value greater than 1000 nM for the rat 5-HT transporter. This compound effectively reduces potassium-induced serotonin (5-HT) release, with an IC50 of 240 nM. L-772405 is valuable in exploring serotonergic signaling and could serve as a useful tool in studies of mood disorders and other neurological research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
