Product Data Sheet
LY314228
Catalog No. A29711
LY314228 is a selective 5-HT2 antagonist primarily targeting the 5-HT2A receptor, exhibiting an IC50 of 147.9 nM. With Ki values of 65 nM for 5-HT2A, 1214 nM for 5-HT2B, and 168 nM for 5-HT2C, it demonstrates relative selectivity within the serotonin receptor family. This compound effectively inhibits 5-HT-induced paw edema in ovariectomized female rats, with an ED50 of 6.4 mg/kg, and can serve as a valuable tool for research in neuropharmacology and related fields.
Chemical Information
| Catalog Num | A29711 |
|---|---|
| M. Wt | 368.43 |
| Formula | C20H24N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 182633-54-1 |
| Synonyms | |
| SMILES | CCCC1=C(O)C(C(C)=O)=CC=C1COC2=CC=C(/C=N/NC(N)=N)C=C2 |
Biological Activity
| Description | LY314228 is a selective 5-HT2 antagonist primarily targeting the 5-HT2A receptor, exhibiting an IC50 of 147.9 nM. With Ki values of 65 nM for 5-HT2A, 1214 nM for 5-HT2B, and 168 nM for 5-HT2C, it demonstrates relative selectivity within the serotonin receptor family. This compound effectively inhibits 5-HT-induced paw edema in ovariectomized female rats, with an ED50 of 6.4 mg/kg, and can serve as a valuable tool for research in neuropharmacology and related fields. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
