Product Data Sheet
AZD1134
Catalog No. A29812
AZD1134 is a highly selective antagonist of the 5-HT1B receptor, demonstrating oral bioavailability and significant brain penetration. With IC50 values of 2.9 nM in humans and 0.108 nM in guinea pigs, AZD1134 effectively increases synaptic serotonin levels, indicating its potential in modulating serotonergic activity. This compound is particularly relevant for research into psychiatric disorders, including depression and anxiety.
Chemical Information
| Catalog Num | A29812 |
|---|---|
| M. Wt | 521.58 |
| Formula | C28H32FN5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 442548-99-4 |
| Synonyms | |
| SMILES | O=C(C1=CC(C2=C(O1)C(N3CCN(C)CC3)=CC(F)=C2)=O)NC4=CC=C(N5CCN(C(CC)=O)CC5)C=C4 |
Biological Activity
| Description | AZD1134 is a highly selective antagonist of the 5-HT1B receptor, demonstrating oral bioavailability and significant brain penetration. With IC50 values of 2.9 nM in humans and 0.108 nM in guinea pigs, AZD1134 effectively increases synaptic serotonin levels, indicating its potential in modulating serotonergic activity. This compound is particularly relevant for research into psychiatric disorders, including depression and anxiety. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
