Product Data Sheet
Vortioxetine-d3
Catalog No. A29824
Vortioxetine-d3 is a stable isotope labeled derivative of Vortioxetine, which primarily acts as an antagonist of the 5-HT3A and 5-HT7 receptors, exhibiting high affinity with Ki values of 3.7 nM and 19 nM, respectively. Additionally, it serves as a potent inhibitor of the serotonin transporter (SERT) with a Ki of 1.6 nM, and functions as a 5-HT1A agonist and a partial agonist at the 5-HT1B receptor, showing Ki values of 15 nM and 33 nM. This compound is valuable for pharmacokinetic studies and research related to serotonin modulation in various neurological and psychiatric disorders.
Chemical Information
| Catalog Num | A29824 |
|---|---|
| M. Wt | 301.46 |
| Formula | C18H19D3N2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1629684-22-5 |
| Synonyms | Lu AA 21004-d3 |
| SMILES | [2H]C([2H])([2H])C1=CC(C)=C(SC2=C(N3CCNCC3)C=CC=C2)C=C1 |
Biological Activity
| Description | Vortioxetine-d3 is a stable isotope labeled derivative of Vortioxetine, which primarily acts as an antagonist of the 5-HT3A and 5-HT7 receptors, exhibiting high affinity with Ki values of 3.7 nM and 19 nM, respectively. Additionally, it serves as a potent inhibitor of the serotonin transporter (SERT) with a Ki of 1.6 nM, and functions as a 5-HT1A agonist and a partial agonist at the 5-HT1B receptor, showing Ki values of 15 nM and 33 nM. This compound is valuable for pharmacokinetic studies and research related to serotonin modulation in various neurological and psychiatric disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
