Product Data Sheet
NAS-181 free base
Catalog No. A29826
NAS-181 free base is a potent and selective antagonist of the rat 5-HT1B receptor, exhibiting a Ki value of 47 nM. This compound demonstrates a 13-fold selectivity for the rat 5-HT1B over the bovine 5-HT1B receptor, which has a Ki of 630 nM. NAS-181 free base effectively enhances serotonin turnover and increases synaptic serotonin levels by inhibiting the terminal rat 5-HT1B autoreceptors, making it a valuable tool for research in neuropharmacology and serotonergic signaling.
Chemical Information
| Catalog Num | A29826 |
|---|---|
| M. Wt | 346.42 |
| Formula | C19H26N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 205242-61-1 |
| Synonyms | |
| SMILES | [C@@H]1(CNCCO1)COC2=C3C(C=C(CO3)CN4CCOCC4)=CC=C2 |
Biological Activity
| Description | NAS-181 free base is a potent and selective antagonist of the rat 5-HT1B receptor, exhibiting a Ki value of 47 nM. This compound demonstrates a 13-fold selectivity for the rat 5-HT1B over the bovine 5-HT1B receptor, which has a Ki of 630 nM. NAS-181 free base effectively enhances serotonin turnover and increases synaptic serotonin levels by inhibiting the terminal rat 5-HT1B autoreceptors, making it a valuable tool for research in neuropharmacology and serotonergic signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
