Product Data Sheet
LEK 8841 methanesulfonate
Catalog No. A29868
LEK 8841 methanesulfonate is a selective antagonist of the 5-HT2 receptor, demonstrating notable gastrointestinal calming properties. It exhibits strong competitive antagonism towards 5-HT and norepinephrine, with pA2 values of 7.93 and 6.45, respectively. LEK 8841's superior selectivity compared to other antagonists makes it a valuable reference compound in receptor research. Additionally, studies on structural modifications indicate that LEK 8841 possesses a high affinity for 5-HT2 receptors while exhibiting minimal activity at alpha-adrenergic receptors, enhancing its potential for therapeutic applications in psychopharmacology.
Chemical Information
| Catalog Num | A29868 |
|---|---|
| M. Wt | 494.40 |
| Formula | C21H24BrN3O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 145204-80-4 |
| Synonyms | |
| SMILES | BrC1=C2C3=C(C4=C[C@@H](C(N(C)CC#C)=O)CN(C)[C@]4([H])C2)C=CC=C3N1.CS(=O)(O)=O |
Biological Activity
| Description | LEK 8841 methanesulfonate is a selective antagonist of the 5-HT2 receptor, demonstrating notable gastrointestinal calming properties. It exhibits strong competitive antagonism towards 5-HT and norepinephrine, with pA2 values of 7.93 and 6.45, respectively. LEK 8841's superior selectivity compared to other antagonists makes it a valuable reference compound in receptor research. Additionally, studies on structural modifications indicate that LEK 8841 possesses a high affinity for 5-HT2 receptors while exhibiting minimal activity at alpha-adrenergic receptors, enhancing its potential for therapeutic applications in psychopharmacology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
