Product Data Sheet
Cariprazine-d8-1 (RGH-188-d8-1)
Catalog No. A29892
Cariprazine-d8 is a deuterated form of Cariprazine, a novel antipsychotic agent primarily targeting dopamine D3 and D2 receptors with high affinities of Ki = 0.085 nM and Ki = 0.49 nM, respectively. It also shows moderate affinity for the serotonin receptor 5-HT1A (Ki = 2.6 nM). This stable isotope-labeled compound enables enhanced pharmacokinetic studies and metabolic profiling in research applications, contributing valuable insights into therapeutic mechanisms and drug interactions.
Chemical Information
| Catalog Num | A29892 |
|---|---|
| M. Wt | 435.46 |
| Formula | C21H24D8Cl2N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1308278-69-4 |
| Synonyms | RGH-188-d8 |
| SMILES | ClC1=C(C=CC=C1Cl)N2CCN(CC2)C([2H])(C[C@H]3CC[C@@H](CC3)NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)[2H] |
Biological Activity
| Description | Cariprazine-d8 is a deuterated form of Cariprazine, a novel antipsychotic agent primarily targeting dopamine D3 and D2 receptors with high affinities of Ki = 0.085 nM and Ki = 0.49 nM, respectively. It also shows moderate affinity for the serotonin receptor 5-HT1A (Ki = 2.6 nM). This stable isotope-labeled compound enables enhanced pharmacokinetic studies and metabolic profiling in research applications, contributing valuable insights into therapeutic mechanisms and drug interactions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
