Product Data Sheet
Prucalopride hydrochloride
Catalog No. A29910
Prucalopride hydrochloride is a selective and specific agonist for the 5-HT4 receptor, with high affinity identified by pKis of 8.6 and 8.1 for the human 5-HT4a and 4b subtypes, respectively. This compound enhances intestinal motility by facilitating the regeneration of the intestinal nervous system, as demonstrated in rodent models. Additionally, Prucalopride hydrochloride exhibits anticancer properties through the inhibition of the PI3K/AKT/mTOR signaling pathway. Its applications are relevant in research focused on chronic constipation, pseudo-intestinal obstruction, and cancer.
Chemical Information
| Catalog Num | A29910 |
|---|---|
| M. Wt | 404.33 |
| Formula | C18H27Cl2N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 179474-80-7 |
| Synonyms | |
| SMILES | ClC1=C(N)C(CCO2)=C2C(C(NC3CCN(CCCOC)CC3)=O)=C1.Cl |
Biological Activity
| Description | Prucalopride hydrochloride is a selective and specific agonist for the 5-HT4 receptor, with high affinity identified by pKis of 8.6 and 8.1 for the human 5-HT4a and 4b subtypes, respectively. This compound enhances intestinal motility by facilitating the regeneration of the intestinal nervous system, as demonstrated in rodent models. Additionally, Prucalopride hydrochloride exhibits anticancer properties through the inhibition of the PI3K/AKT/mTOR signaling pathway. Its applications are relevant in research focused on chronic constipation, pseudo-intestinal obstruction, and cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
