Product Data Sheet
Frovatriptan succinate
Catalog No. A29916
Frovatriptan succinate is a selective agonist of the 5-HT1B and 5-HT1D receptors, exhibiting a pK50 of 8.2. This compound demonstrates greater than 10-fold selectivity for the targeted receptors compared to 5-HT1A, 5-HT1F, and 5-HT7, and over 1000-fold selectivity against various other receptors, including dopamine, histamine H1, and α1-adrenoceptors. Frovatriptan succinate is primarily utilized in migraine research, providing valuable insights into the mechanisms underlying migraine pathophysiology and potential therapeutic interventions.
Chemical Information
| Catalog Num | A29916 |
|---|---|
| M. Wt | 361.39 |
| Formula | C18H23N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 158930-09-7 |
| Synonyms | (R)-Frovatriptan succinate; SB 209509 succinate; VML 251 succinate |
| SMILES | O=C(O)CCC(O)=O.O=C(C1=CC2=C(NC3=C2C[C@H](NC)CC3)C=C1)N |
Biological Activity
| Description | Frovatriptan succinate is a selective agonist of the 5-HT1B and 5-HT1D receptors, exhibiting a pK50 of 8.2. This compound demonstrates greater than 10-fold selectivity for the targeted receptors compared to 5-HT1A, 5-HT1F, and 5-HT7, and over 1000-fold selectivity against various other receptors, including dopamine, histamine H1, and α1-adrenoceptors. Frovatriptan succinate is primarily utilized in migraine research, providing valuable insights into the mechanisms underlying migraine pathophysiology and potential therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
