Product Data Sheet
GR-4991W93
Catalog No. A29926
GR-4991W93 is an orally active partial agonist of the 5HT1B and 5HT1D receptors, showing pIC50 values of 6.95 and 7.80, respectively. This compound exhibits significant inhibition of electrically evoked plasma extravasation in guinea pig models, demonstrating its pharmacological potential in modulating neurogenic inflammation. GR-4991W93 is suitable for use in migraine research, offering insights into the mechanisms underlying this condition.
Chemical Information
| Catalog Num | A29926 |
|---|---|
| M. Wt | 313.39 |
| Formula | C18H23N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 171549-56-7 |
| Synonyms | |
| SMILES | CN(C)[C@H](C1)C[C@@H]1C2=CNC3=CC=C(C[C@@H]4NC(OC4)=O)C=C32 |
Biological Activity
| Description | GR-4991W93 is an orally active partial agonist of the 5HT1B and 5HT1D receptors, showing pIC50 values of 6.95 and 7.80, respectively. This compound exhibits significant inhibition of electrically evoked plasma extravasation in guinea pig models, demonstrating its pharmacological potential in modulating neurogenic inflammation. GR-4991W93 is suitable for use in migraine research, offering insights into the mechanisms underlying this condition. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
