Product Data Sheet
LY 367265
Catalog No. A29932
LY 367265 is a potent inhibitor of the serotonin transporter (SERT) with an IC₅₀ value of 3.1 nM and also serves as a selective antagonist for the 5-HT₂A receptor (Kᵢ = 0.81 nM). It displays minimal activity on the norepinephrine transporter (NET) and low affinity for other serotonin receptor subtypes, reinforcing its selectivity. LY 367265 enhances the efflux of [³H]5-HT in a concentration-dependent manner (EC₅₀ = 250 nM) and can counteract the contraction induced by Sumatriptan, indicating its antagonistic effects on 5-HT₁D-like receptors. This compound is valuable for research into neurological disorders, including anxiety and post-traumatic stress disorder.
Chemical Information
| Catalog Num | A29932 |
|---|---|
| M. Wt | 452.54 |
| Formula | C24H25FN4O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 210751-39-6 |
| Synonyms | |
| SMILES | O=S1(N(CCN2CC=C(CC2)C3=CNC4=C3C=CC(F)=C4)C5=CC=CC6=C5N1CCC6)=O |
Biological Activity
| Description | LY 367265 is a potent inhibitor of the serotonin transporter (SERT) with an IC₅₀ value of 3.1 nM and also serves as a selective antagonist for the 5-HT₂A receptor (Kᵢ = 0.81 nM). It displays minimal activity on the norepinephrine transporter (NET) and low affinity for other serotonin receptor subtypes, reinforcing its selectivity. LY 367265 enhances the efflux of [³H]5-HT in a concentration-dependent manner (EC₅₀ = 250 nM) and can counteract the contraction induced by Sumatriptan, indicating its antagonistic effects on 5-HT₁D-like receptors. This compound is valuable for research into neurological disorders, including anxiety and post-traumatic stress disorder. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
