Product Data Sheet
Naratriptan-d3 hydrochloride
Catalog No. A29972
Naratriptan-d3 hydrochloride is a selective agonist of the 5-HT1B/1D receptors. This deuterium-labeled derivative exhibits effective vasoconstrictive properties on cranial arteries through activation of these receptors, with an EC50 value of 0.11 μM observed in dog basilar arteries. Additionally, it is known to inhibit trigeminal nerve-mediated dural neurogenic plasma extravasation and mitigate sterile inflammation. Naratriptan-d3 hydrochloride is primarily utilized in research focusing on acute migraine, particularly related to cranial vascular dynamics and neuroinflammatory responses.
Chemical Information
| Catalog Num | A29972 |
|---|---|
| M. Wt | 374.94 |
| Formula | C17H23D3ClN3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1190021-64-7 |
| Synonyms | GR-85548A d3 |
| SMILES | CNS(CCC1=CC=C(NC=C2C3CCN(C([2H])([2H])[2H])CC3)C2=C1)(=O)=O.[H]Cl |
Biological Activity
| Description | Naratriptan-d3 hydrochloride is a selective agonist of the 5-HT1B/1D receptors. This deuterium-labeled derivative exhibits effective vasoconstrictive properties on cranial arteries through activation of these receptors, with an EC50 value of 0.11 μM observed in dog basilar arteries. Additionally, it is known to inhibit trigeminal nerve-mediated dural neurogenic plasma extravasation and mitigate sterile inflammation. Naratriptan-d3 hydrochloride is primarily utilized in research focusing on acute migraine, particularly related to cranial vascular dynamics and neuroinflammatory responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
